SKU: 37289196452

Aliye Bricker, M.D.

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Description

Aliye Bricker, M.D.RETpositives founder, our North Star, passed away from Stage IV NSCLC in February 2022. She was deeply committed to finding next generation RET therapies. We continue the fight in her honor and all of our fellow RET warriors as we work together to make RET altered cancer just another chronic disease. "I was already stage IV by the time I was diagnosed in late 2015. I was a 34 year old never smoker with a 4 year old, pregnant with my second daughter

RETpositive’s founder, our North Star, passed away from Stage IV NSCLC in February 2022. She was deeply committed to finding next generation RET therapies. We continue the fight in her honor and all of our fellow RET warriors as we work together to make RET-altered cancer just another chronic disease.

"I was already stage IV by the time I was diagnosed in late 2015. I was a 34-year-old never-smoker with a 4-year-old, pregnant with my second daughter while still working as a full-time physician (Neuroradiologist). When I developed a dry, nagging cough in the last few weeks of my pregnancy, my Obstetrician and I wanted to wait until the delivery to get a chest X-ray to avoid any radiation to my unborn baby. The day after my delivery, my chest X-Ray showed a lung mass and pleural effusions, and I was put on antibiotics for presumed pneumonia (even though I never had a fever). Five days later my effusion was drained, leading to my diagnosis with NSCLC. It had already spread to my brain and bones. This terminal diagnosis came as a complete shock. A quick google search informed me that my chances of being alive in five years were about 1%.

"I started off my maternity leave with gamma knife to my solitary brain metastasis and I started chemotherapy (Carboplatin plus Alimta) right away. I had a pleurex catheter placed for my recurrent effusions which came out eight months later. Luckily for me, my oncologist sent my tumor sample for genetic testing and a RET driver mutation was found. Although there were no RET-targeted treatments at the time of my diagnosis, finding RET was still a source of hope.

"After first-line chemotherapy stopped working, I tried (and failed) immunotherapy,  tried (and failed) one of the earlier multikinase inhibitors (cabozantinib), and I developed liver mets to add to my collection, before losing all of my hair with second-line chemotherapy (Docetaxol plus carboplatin.) By the end of the summer in 2017, I was bald and entirely dependent on oxygen, even at rest, and nearly out of treatment options. When the Selpercatinib trial opened at my institution, the Cleveland Clinic, in September 2017 I was the first to enroll, and within three weeks I was no longer oxygen-dependent. This first-generation RET-targeting tyrosene kinase inhibitor (TKI) gave me my life back and by that October, I was trick-or-treating with my kids (without any supplemental oxygen!).

"I’ve now been on Selpercatinib (Retevmo) for 3.5+ years and counting, and have experienced first-hand that medical research does save lives. Most recently in December 2020 my scans did show some small pleural lesions and a nodule in my lung that have been very slowly progressing, for which I underwent stereotactic radiation in January 2021. Most recent scans were encouraging, and I've learned how important it is to take everything one day at a time. My daughters are now five- and ten-years-old and I'm thankful for every day!"

 

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SKU: 37289196452

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4.8 ★★★★★
Based on 20 reviews
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Verified Purchase
Amanda Cárdenas
Pawtucket, US
★★★★★ 5
Finos y cómodos
Size: 9, Color: Taupe
Tal cual muestra la descripción y las fotos. Cumplió nuestra espectativas la compra. Finos y cómodos
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Reviewed in the United States on April 26, 2026
E
Verified Purchase
End Buyer
Draper, US
★★★★★ 5
For slim feet
Size: 13, Color: Black
Had to send both pair back. Nice shoe but their size 12 was to narrow for my feet. Pitty, as they looked and felt great in the box. Got a slender foot? Try these.
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Reviewed in the United States on March 16, 2026
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Verified Purchase
Jesse C.
Pawtucket, US
★★★★★ 1
Cheap quality
Size: 11, Color: Cognac
I hardly ever leave reviews because most everything is as expected. However these shoes, although they look nice and if you apply a polish they look even better, just aren’t worth it. They are offered at a good price, but don’t live up to even that cost. As others mentioned the stitching came undone within the 2nd day of use. I had to break out the needle to put the thread back in so they wouldn’t fall apart. That problem fixed didn’t stop the issues. Within a couple more weeks of use the leather started peeling on the tip of the shoes and thus lost all future use. You would be better off buying a more expensive pair with better quality leather and stitching.
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Reviewed in the United States on January 3, 2026
S
Verified Purchase
SMReno
Natrona Heights, US
★★★★★ 5
Exactly What I Was Looking For
Size: 8.5, Color: Cognac
Love these shoes and were exactly what I was looking for. Stylish and go with so many different styles plus they’re extremely comfortable and lightweight.
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Reviewed in the United States on March 19, 2026
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Verified Purchase
Jp fish
Birmingham, US
★★★★★ 5
Would recommend
These shoes have quickly become my go-to shoes for everyday wear. First off, the fit and comfort are fantastic right out of the box — no breaking-in period needed. They feel supportive without being stiff, and I can wear them all day without my feet getting tired. I really like the look too. They strike a nice balance between casual and polished, so they work with jeans, chinos, or even smart-casual outfits. The design isn’t too loud or flashy, but they still look sharp enough for dinners, errands, or work-from-home Zoom calls. One thing I love is how easy they are to slip on and off. No laces to fuss with, and the elastic stretch makes getting them on quick and easy — perfect for mornings when I’m rushing out the door. They also feel versatile. I’ve worn them for walking around town, to casual office days, and even a weekend brunch, and they’ve suited every situation without looking out of place. Overall the quality feels solid for the price — good stitching, durable materials, and so far no signs of wear after a few weeks of frequent use. Comfort, style, and convenience all in one pair. If you want casual loafers that look good and feel great without any fuss, these are definitely worth checking out.
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Reviewed in the United States on February 3, 2026

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