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Description
K9 Advantix II XL Dog Flea, Tick & Mosquito Treatment & PreventionK9 Advantix II Extra Large Dog is the veterinarian recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing
K9 Advantix II Extra Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult fleas on contact so they can’t lay eggs and they don’t have to bite your dog to die. Fleas, ticks, mosquitoes and other pests not only cause discomfort; they may also transmit disease. Monthly use of K9 Advantix II is important to protect your dog against fleas that may cause transmission of tapeworms. This formula also kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia. That’s why K9 Advantix II Extra Large Dog topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that K9 Advantix II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh over 55 lbs. to use K9 Advantix II Extra Large Dog. For the ultimate convenience in care, K9 Advantix II is available over the counter – no prescription needed. And, you can stock up with 2-dose, 4-dose and 6-dose packs so you never miss a monthly treatment. Once K9 Advantix II is applied, your dog is ready to get right back to big-pup cuddles and racing around the park. K9 Advantix II Extra Large Dog is a trademark of Elanco or its affiliates.
Key Features
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K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
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Kills fleas within 12 hours of application
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Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
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Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
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No prescription needed
Directions for Use
Use only on dogs. DO NOT USE ON CATS or other animals. Do not apply to dogs weighing less than 4 lbs. Remove applicator tube from the package. Use scissors and peel down foil. Hold applicator tube in an upright position. Pull cap off tube. Turn cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. The dog should be standing for easy application. Evenly apply entire contents of the tube along the top of the dog's back, from the shoulder down to the base of the tail. The number of spots depends on the size and weight of your dog (please refer to the product label). At each spot, part the hair until skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your dog’s eyes, or allow your dog to ingest this product.
Storage Instructions
Store in a cool, dry place inaccessible to children and pets. Protect from freezing.
Active Ingredients
Imidacloprid, Permethrin, Pyriproxyfen
Product Form
- Topical
Pet Size
- Extra Large
Pet Lifestage
- 7 weeks and older
Pet Weight
Over 55 lbs
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.0 ★★★★★
Based on 6 reviews
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Product Reviews
★★★★★ 5
Durable fun enrichment toy
Size: 1 Pack, Style: Pawbler
I had been wanting to buy one of these kinds of toys for some time but thought that the other brands I had seen were too pricey so this was a great compromise for the price. My 5 yr old Portuguese water dog loves it. He spent 25 min playing with it the first day. The trick is to find a treat that is just big enough where it doesn’t fall out right away so it makes it challenging and fun for them. He has been chewing on it a lot for a week and it has not broken or shown signs of damage. One thing to note is that there is a small hole on the bottom of the toy so you cannot freeze liquids in it without covering the hole in some way so that would be my only complaint. Besides that it’s a great toy that keeps him busy and happy.
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Reviewed in the United States on September 1, 2025
★★★★★ 3
Dog doesn’t care for it
Size: 1 Pack, Style: Bone
Hard to review product for its durability because my dog has never chewed it once. Doesn’t care about it at all. The bone feels rugged but smells like playdoh. It’s sat on the floor for over a month untouched.
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Reviewed in the United States on May 6, 2026
★★★★★ 1
Pawbler FAIL: First time our dog bit the ball, it popped open and dumped all the kibble.
Size: 1 Pack, Style: Pawbler
I would not recommend! We have a 48# dog and within minutes of giving it to him, the Pawbler was open and all of the kibble was in a pile on the ground. I had washed and dried the Pawbler, added kibble, and tightened the lid as tight as possible. Imagine my surprise when, within minutes of giving it to him, the lid was off and all the kibble was on the ground. I thought it was a fluke so then I made an extra effort to make sure the lid was super tight...and the same thing happened. This time there was no food inside so he started chewing on the two parts. Within minutes of that, he'd chewed/damaged the rubber on both the body and the lid. I took it away as I didn't want him to destroy/eat any of the rubber bits. I was surprised he could even get the Pawbler in his mouth. It's heavy and he is a medium sized dog. He has the Benebone Bone, the WestPaw bone, the WestPaw ring that he chews on all of the time and none of those are showing any type of wear so to see this opened/chewed within 15 minutes makes me think this was defective. I am returning and hoping for a refund. DO NOT BUY! Poor value for the money. Not durable. Not chew resistant.
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Reviewed in the United States on April 30, 2026
★★★★★ 5
Just what I was looking for to slow my large dog while eating
Size: 1 Pack, Style: Pawbler, Size: 1 Pack, Style: Pawbler
I needed something for my 50-pound dog to slow down her eating. The usual slow-feeder bowls and mats weren't really slowing her down much and I wanted her to have to think a little bit. She's not smart enough for puzzles though. So I got this kibble dispensing toy. My dog is not a chewer so I don't have to worry about her destroying it.
LOVE: holds a little more than a cup of kibble, dispenses different sized kibbles, heavy weight so it wobbled around a lot without going too far away, QUIET- I couldn't bear the noise of hard plastic dispensers clacking around and this one is very quiet on our hardwood floors, kept the dog busy for at least 20 minutes. It's really all I was hoping it would be. And, well, as you can see in the video, the cat is happy about it too...
As with all of these dispensers, there will be a couple of kibbles left inside that are hard to get out. But that gave my dog something to do overnight. She spent a long time getting that last kibble out. The slight scent they add to the natural rubber is not a problem at all. This dispenser is absolutely worth the money, it's going to last us a very, very long time.
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Reviewed in the United States on October 17, 2025
★★★★★ 5
People are doin it wrong
Size: 1 Pack, Style: Cone
Cheap and durable and huge. The bad reviews are from people who aren’t using it right. Step 1) plug hole with a smear of peanut butter. 2) put a low calorie but appetizing mix of whatever you want: yogurt, pate, pumpkin puree, blended with frozen veggies on the walls 3) freeze cone for 30 mins. Hole will be sufficiently plugged to add liquid. 4) fill the rest with water or bone broth and freeze overnight to make it a changing ice block.
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Reviewed in the United States on May 4, 2026